ASTM-D7644 2010

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D7644-10 Standard Test Method for Determination of Bromadiolone, Brodifacoum, Diphacinone and Warfarin in Water by Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

Published By	Publication Date	Number of Pages
ASTM	2010	15

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Categories: 13.060.50 - Examination of water for chemical substances, ASTM

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Description

1.1 This procedure covers the determination of bromadiolone, brodifacoum, diphacinone and warfarin (referred to collectively as rodenticides in this test method) in water by direct injection using liquid chromatography (LC) and detected with tandem mass spectrometry (MS/MS). These analytes are qualitatively and quantitatively determined by this method. This method adheres to multiple reaction monitoring (MRM) mass spectrometry.

1.2 The Detection Verification Level (DVL) and Reporting Range for the rodenticides are listed in Table 1.

1.2.1 The DVL is required to be at a concentration at least 3 times below the Reporting Limit (RL) and have a signal/noise ratio greater than 3:1. Fig. 1 displays the signal/noise ratios of the primary single reaction monitoring (SRM) transitions, and Fig. 2 displays the confirmatory SRM transitions at the DVLs for the rodenticides.

1.2.2 The reporting limit was calculated from the concentration of the Level 1 calibration standard, as shown in Table 4, accounting for the dilution of a 40 mL water sample up to a final volume of 50 mL with methanol to ensure analyte solubility.

1.3 Units The values stated in SI units are to be regarded as standard. No other units of measurement are included in this standard.

1.4 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.

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PDF Pages	PDF Title
1	Scope Referenced Documents TABLE 1
2	FIG. 1 FIG. 2
3	Terminology Summary of Test Method Significance and Use Interferences Apparatus
4	Reagents and Materials Hazards Sampling Preparation of LC/MS/MS
5	Calibration and Standardization TABLE 2
6	TABLE 3 TABLE 4
7	TABLE 5
8	Procedure Calculation or Interpretation of Results TABLE 6
9	Report Precision and Bias TABLE 7
10	TABLE 8 TABLE 9
11	Keywords TABLE 10 TABLE 11
12	TABLE 12 TABLE 13
13	TABLE 14 TABLE 15
14	X1. HOLDING TIME STUDY X1.1 TABLE 16
15	FIG. X1.1

Additional information

Standard Title	D7644-10 Standard Test Method for Determination of Bromadiolone, Brodifacoum, Diphacinone and Warfarin in Water by Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)
Published Code	ASTM
Publication Date	2010
Pages Count	15
ICS Codes	13.060.50 - Examination of water for chemical substances

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ASTM-D7644 2010

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