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ASTM-D6122:2006 Edition

ASTM-D6122:2006 Edition

$58.50

D6122-06 Standard Practice for Validation of the Performance of Multivariate Process Infrared Spectrophotometers

Published By Publication Date Number of Pages
ASTM 2006 29
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1.1 This practice covers requirements for the validation of measurements made by online, process near- or mid-infrared analyzers, or both, used in the calculation of physical, chemical, or quality parameters (that is, properties) of liquid petroleum products. The properties are calculated from spectroscopic data using multivariate modeling methods. The requirements include verification of adequate instrument performance, verification of the applicability of the calibration model to the spectrum of the sample under test, and verification of equivalence between the result calculated from the infrared measurements and the result produced by the primary test method used for the development of the calibration model. When there is adequate variation in property level, the statistical methodology of Practice D 6708 is used to provide general validation of this equivalence over the complete operating range of the analyzer. For cases where there is inadequate property variation, methodology for level specific validation is used.

1.2 Performance Validation is conducted by calculating the precision and bias of the differences between results from the analyzer system (or subsystem) produced by application of the multivariate model, (such results are herein referred to as Predicted Primary Test Method Results (PPTMRs)), versus the Primary Test Method Results (PTMRs) for the same sample set. Results used in the calculation are for samples that are not used in the development of the multivariate model. The calculated precision and bias are statistically compared to user-specified requirements for the analyzer system application.

1.2.1 For analyzers used in product release or product quality certification applications, the precision and bias requirement for the degree of agreement are typically based on the site or published precision of the Primary Test Method.

Note 1

In most applications of this type, the PTM is the specification-cited test method.

1.2.2 This practice does not does not describe procedures for establishing precision and bias requirements for analyzer system applications. Such requirements must be based on the criticality of the results to the intended business application and on contractual and regulatory requirements. The user must establish precision and bias requirements prior to initiating the validation procedures described herein.

1.3 This practice does not cover procedures for establishing the calibration model (correlation) used by the analyzer. Calibration procedures are covered in Practices E 1655 and references therein.

1.4 This practice is intended as a review for experienced persons. For novices, this practice will serve as an overview of techniques used to verify instrument performance, to verify model applicability to the spectrum of the sample under test, and to verify equivalence between the parameters calculated from the infrared measurement and the results of the primary test method measurement.

1.5 This practice teaches and recommends appropriate statistical tools, outlier detection methods, for determining whether the spectrum of the sample under test is a member of the population of spectra used for the analyzer calibration. The statistical tools are used to determine if the infrared measurement results in a valid property or parameter estimate.

1.6 The outlier detection methods do not define criteria to determine whether the sample or the instrument is the cause of an outlier measurement. Thus, the operator who is measuring samples on a routine basis will find criteria to determine that a spectral measurement lies outside the calibration, but will not have specific information on the cause of the outlier. This practice does suggest methods by which instrument performance tests can be used to indicate if the outlier methods are responding to changes in the instrument response.

1.7 This practice is not intended as a quantitative performance standard for the comparison of analyzers of different design.

1.8 Although this practice deals primarily with validation of online, process infrared analyzers, the procedures and statistical tests described herein are also applicable to at-line and laboratory infrared analyzers which employ multivariate models.

This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.

PDF Catalog

PDF Pages PDF Title
1 Scope
2 Referenced Documents
Terminology
4 Summary of Practice
5 Significance and Use
Apparatus and Considerations for Quantitative Online Process IR Measurements
6 Preconditions
Reference Values and the Quality Assurance Program for the Primary Test Method
Procedure
7 FIG. 1
8 FIG. 1
9 FIG. 2
10 FIG. 3
12 Performance Tests
13 Verification that the Model is Applicable to the Spectrum of the Process Stream Sample—Spectral Outlier and Nearest Neighbor Inlier Detection
14 Analyzer System Probationary and General Validation
TABLE 1
15 TABLE 2
TABLE 3
16 FIG. 4
17 Analyzer System Level Specific Validation
TABLE 4
18 Periodic Continual Validation by Plotting Control Charts of the Differences Between Methods
FIG. 5
19 Updating Control Limits
FIG. 6
20 Analyzer Repeatability
Analyzer Intermediate Precision
21 Keywords
A1. CONSIDERATIONS FOR QUANTITATIVE ONLINE PROCESS IR MEASUREMENTS
A1.1
A1.2 Spectrophotometer Cells and Other Infrared Sampling Methods
TABLE A1.1
22 A1.3 Fiber Optics
A1.4 In-Line Probes
A1.5 Sample Temperature
A2. INSTRUMENT PERFORMANCE TESTS
A2.1 Reference Materials for Instrument
23 A2.2 Types of Performance Tests
25 A2.3 Performance Test Charts
A2.4 Performance Test Action Limits
26 A2.5 Tests for In-Line Probes
27 A3. OUTLIER DETECTION METHODS
A3.1
A3.2 Leverage Test
28 A3.3 Spectral Residuals
TABLE A3.1
29 A3.4 Nearest Neighbor Distance
REFERENCES

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