{"id":338456,"date":"2024-10-19T23:41:03","date_gmt":"2024-10-19T23:41:03","guid":{"rendered":"https:\/\/pdfstandards.shop\/product\/uncategorized\/bs-iso-221862020\/"},"modified":"2024-10-25T22:47:12","modified_gmt":"2024-10-25T22:47:12","slug":"bs-iso-221862020","status":"publish","type":"product","link":"https:\/\/pdfstandards.shop\/product\/publishers\/bsi\/bs-iso-221862020\/","title":{"rendered":"BS ISO 22186:2020"},"content":{"rendered":"<p>This document specifies a liquid chromatography tandem mass spectrometry (LC\u2013MS\/MS) method for the quantification of the inhibitory substance, nitrofurazone, in milk and milk products.<\/p>\n<p>The method has been validated for measuring trace levels of intact nitrofurazone to levels down to 1&nbsp;ng\/g in fluid milk and powdered dairy products on a whole product (i.e. powder) basis. While the method is expected to apply to other dairy matrices, additional validation will be required to demonstrate this.<\/p>\n<h4>PDF Catalog<\/h4>\n<table border=\"1px\" class=\"des-table\">\n<tr>\n<th>PDF Pages<\/th>\n<th>PDF Title<\/th>\n<\/tr>\n<tr>\n<td><b>2<b><\/td>\n<td>National foreword  <\/td>\n<\/tr>\n<tr>\n<td><b>7<b><\/td>\n<td>Foreword  <\/td>\n<\/tr>\n<tr>\n<td><b>9<b><\/td>\n<td>Introduction  <\/td>\n<\/tr>\n<tr>\n<td><b>11<b><\/td>\n<td>1 Scope <br \/> 2 Normative references <br \/> 3 Terms and definitions <br \/> 4 Principle  <\/td>\n<\/tr>\n<tr>\n<td><b>12<b><\/td>\n<td>5 Reagents and reference substances <br \/> 5.1 Reagents and materials  <\/td>\n<\/tr>\n<tr>\n<td><b>13<b><\/td>\n<td>5.2 Reference substances  <\/td>\n<\/tr>\n<tr>\n<td><b>14<b><\/td>\n<td>5.2.7 Standard solutions for calibration by the external calibration curve approach. <br \/> 5.2.8 Solutions for LC\u2013MS\/MS.  <\/td>\n<\/tr>\n<tr>\n<td><b>15<b><\/td>\n<td>6 Apparatus <br \/> 7 Sampling  <\/td>\n<\/tr>\n<tr>\n<td><b>16<b><\/td>\n<td>8 Procedure <br \/> 8.1 Test portion <br \/> 8.1.1 Liquid milk <br \/> 8.1.2 Powdered dairy products <br \/> 8.2 Extraction procedure <br \/> 8.3 Reagent blank  <\/td>\n<\/tr>\n<tr>\n<td><b>17<b><\/td>\n<td>8.4 Positive quality control <br \/> 8.4.1 General <br \/> 8.4.2 Liquid milk <br \/> 8.4.3 Powdered dairy products <br \/> 8.4.4 Calculations <br \/> 8.5 Matrix-matched calibration curves <br \/> 8.5.1 General  <\/td>\n<\/tr>\n<tr>\n<td><b>18<b><\/td>\n<td>8.5.2 Matrix-matched calibration samples for fluid milk <br \/> 8.5.3 Matrix-matched calibration samples for powdered dairy products <br \/> 8.6 LC\u2013MS\/MS conditions <br \/> 8.6.1 General <br \/> 8.6.2 Chromatographic conditions  <\/td>\n<\/tr>\n<tr>\n<td><b>19<b><\/td>\n<td>8.6.3 MS\/MS conditions  <\/td>\n<\/tr>\n<tr>\n<td><b>20<b><\/td>\n<td>8.7 Sequence set-up <br \/> 9 Calculation and expression of results <br \/> 9.1 General <br \/> 9.2 Peak integration  <\/td>\n<\/tr>\n<tr>\n<td><b>21<b><\/td>\n<td>9.3 Calibration curves <br \/> 9.3.1 External calibration curve from external calibration standards <br \/> 9.3.2 Matrix-matched calibration curve from matrix-matched calibration standards <br \/> 9.4 Identification and confirmation <br \/> 9.5 Calculation using external calibration curve  <\/td>\n<\/tr>\n<tr>\n<td><b>22<b><\/td>\n<td>9.6 Calculation using matrix-matched calibration curve <br \/> 9.7 Expression of results <br \/> 10 Precision <br \/> 10.1 General <br \/> 10.2 Repeatability  <\/td>\n<\/tr>\n<tr>\n<td><b>23<b><\/td>\n<td>10.3 Reproducibility <br \/> 11 Test report  <\/td>\n<\/tr>\n<tr>\n<td><b>24<b><\/td>\n<td>Annex A (informative) Examples of chromatograms  <\/td>\n<\/tr>\n<tr>\n<td><b>25<b><\/td>\n<td>Annex B (informative) Precision data  <\/td>\n<\/tr>\n<tr>\n<td><b>29<b><\/td>\n<td>Bibliography  <\/td>\n<\/tr>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p><b>Milk and milk products. Determination of nitrofurazone<\/b><\/p>\n<table class=\"shortdes-table\" style=\"width: 100%\" border=\"0\" cellspacing=\"0\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td>Published By<\/td>\n<td>Publication Date<\/td>\n<td>Number of Pages<\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/pdfstandards.shop\/product-category\/publishers\/bsi\/\"><b>BSI<\/b><\/a><\/td>\n<td>2020<\/td>\n<td>30<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"featured_media":338461,"template":"","meta":{"rank_math_lock_modified_date":false,"ep_exclude_from_search":false},"product_cat":[959,2641],"product_tag":[],"class_list":{"0":"post-338456","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-67-100-01","7":"product_cat-bsi","9":"first","10":"instock","11":"sold-individually","12":"shipping-taxable","13":"purchasable","14":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/product\/338456","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/media\/338461"}],"wp:attachment":[{"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/media?parent=338456"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/product_cat?post=338456"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/product_tag?post=338456"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}